inflammatory bowel disease (ibd) — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T1752	NS6180		Potassium Channel
	NS6180 is a potent and selective KCa3.1 channel inhibitor(IC50= 9 nM). It prevents T-cell activation and inflammation.		Potassium Channel
T2718	Palmatine chloride		Others , Indoleamine 2,3-Dioxygenase (IDO) , Aurora Kinase
	Palmatine chloride an isoquinoline alkaloid, is an important medicinal herbal extract with diverse pharmacological and biological properties.		Others , Indoleamine 2,3-Dioxygenase (IDO) , Aurora Kinase
T5S0802	Palmatine	Berbericinine,Burasaine	Indoleamine 2,3-Dioxygenase (IDO) , AChR , AChE , Aurora Kinase
	1. Palmatine (Burasaine) is an inhibitor of dopamine generation. 2. Palmatine could potentially be developed for the treatment of flavivirus infections. 3. Palmatine has been used in the treatment of jaundice, dysentery,...
T4084	Sibofimloc	VRT-1353385,Antibiotic-202,Antibiotic 202	Antibacterial , Antibiotic
	Sibofimloc (Antibiotic-202), an antibiotic compound, is used in treating bacterial infections.		Antibacterial , Antibiotic
T2601	Vidofludimus	SC12267,4sc-101	Dehydrogenase , DNA/RNA Synthesis , Interleukin
	Vidofludimus (SC12267) (4SC-101, SC12267) is a novel small molecule inhibitor of dihydroorotate dehydrogenase (DHODH).		Dehydrogenase , DNA/RNA Synthesis , Interleukin
T24997	ABT-510 acetate	ABT 510 acetate	Apoptosis
	ABT-510 acetate is an endogenous anti-angiogenic TSP peptide inhibitor, a thrombospondin analog, with anti-inflammatory, anti-cancer and anti-angiogenic activity that induces apoptosis and inhibits ovarian tumor growth i...		Apoptosis
T79600	Zharp2-1		RIP kinase
	Zharp2-1, a RIPK2 inhibitor, inhibits the transcription of inflammatory cytokines induced by MDP-induced or Listeria monocytogenes infection and alleviates MDP-induced peritonitis symptoms in mice, which can be used for ...		RIP kinase
T9975	GPR183	3-(3,4-difluorophenyl)-N-[3-fluoro-5-(morpholin-4-yl)phenyl]propanamide	Others
	GPR183 (3-(3,4-difluorophenyl)-N-[3-fluoro-5-(morpholin-4-yl)phenyl]propanamide) is a chemotactic receptor known for its role in the maturation of B cells, and the endogenous ligand is the oxysterol 7α,25-dihydroxycholes...		Others
T38944	Tetomilast	OPC-6535,Tetomilast
	Tetomilast (OPC-6535) is a phosphodiesterase-4 (PDE4) inhibitor, potentially effective in treating inflammatory bowel disease (IBD) and chronic obstructive pulmonary disease (COPD).
T62462	RORγt/DHODH-IN-2
	RORγt/DHODH-IN-2 (compound 1) is a potent dual RORγt/DHODH inhibitor that can be used in the study of inflammatory bowel disease (IBD).
T7749	ALB-127158
	ALB-127158(a) is a potent and selective melanin concentrating hormone 1 ( MCH 1 ) receptor antagonist which may be a potential treatment for inflammatory bowel disease (IBD).
T82223	HDHODH-IN-13
	hDHODH-IN-13 (compound w2), an inhibitor of human dihydroorotate dehydrogenase (hDHODH), exhibits an IC50 of 173.4 nM and has potential research applications in studying inflammatory bowel disease (IBD) [1].
T76737	Abrilumab
	Abrilumab, a fully human monoclonal antibody, targets the α4β7 integrin heterodimer, selectively binding to it. This specificity makes it a potential research tool for investigating inflammatory bowel disease (IBD) [1].
T79385	PDE1-IN-5
	PDE1-IN-5 (Compound 10c) is a selective PDE1C inhibitor with an IC50 of 15 nM, exhibiting anti-inflammatory properties through the inhibition of iNOS, TNF-α, IL-1α, IL-1β, and IL-6 expression induced by LPS. It has demon...
T76057	Glepaglutide acetate
	Glepaglutide (ZP1848) acetate is a long-acting glucagon-like peptide-2 (GLP-2) analogue and a potent GLP-2 receptor (GLP-2R) agonist. It significantly reduces fecal output and enhances intestinal absorption while also mi...
T76056	Glepaglutide
	Glepaglutide (ZP1848), a long-acting glucagon-like peptide-2 (GLP-2) analogue, functions as a potent agonist of the GLP-2 receptor (GLP-2R), effectively reducing fecal output and enhancing intestinal absorption, while al...
T77154	Etrolizumab
	Etrolizumab (rhuMAb Beta7), a gut-selective anti-β7 integrin monoclonal antibody, targets the β7 subunit of α4β7 and αEβ7 integrins specifically, demonstrating affinity with K i values of 18 nM for Human α4β7 and 1800 pM...
T79527	BET BD2-IN-1		Epigenetic Reader Domain
	BET BD2-IN-1 (compound 45) is a potent, selective inhibitor of BET BD2, exhibiting an IC50 value of 1.6 nM. It suppresses Th17 cell differentiation through the reduced activation of STAT3 and NF-κB, making it relevant in...		Epigenetic Reader Domain
T70899	Vidofludimus hemicalcium	4sc-101 hemicalcium,SC12267 hemicalcium,4sc-101 hemicalcium ; SC12267 hemicalcium
	Vidofludimus hemicalcium (4sc-101; SC12267) is an orally active compound that acts as a dihydroorotate dehydrogenase (DHODH) inhibitor and serves as a novel modulator of the farnesoid X receptor (FXR). This immunomodulat...
T62556	JAK-IN-23
	JAK-IN-23 is an orally active dual JAK/STAT and NF-κB inhibitor that inhibits J AK1 (IC50: 8.9 nM), J AK2 (IC50: 15 nM), and J AK3 (IC50: 46.2 nM). JAK-IN-23 exhibits strong anti-inflammatory effects and can reduce the r...